Snow Cake is a 2006 independent drama starring Alan Rickman and Sigourney Weaver. Shortly after Rickman's character picks up a young hitch-hiker, he is in a sudden, brutal accident and the girl is killed. Paralyzed by guilt, he tries to reconcile with the girl's mother, portrayed by Sigourney Weaver, who happens to be autistic.
That is an intriguing premise. Too bad the film is stunngingly, bafflingly awful.
If Hollywood gravitates toward a "sexy" disability for male characters, it would have to be blindness. I was recently mulling over how the big screen portrays men of color and with disabilities and realized that blind male characters in movies often aren't dehumanized or marginalized. They're downright hot.